Regional police spokesman Alexandru Cotet says the accident appears to have occurred when the bus driver ignored a red light at a train crossing and slammed into a locomotive that was passing by on the railway line.
All the casualties were on the bus, and it was not immediately clear if its driver survived the crash.
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The accident occurred Tuesday in the town of Anenii Noi, 40 kilometers (25 miles) south of the city of Chisinau.
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